Approaches to Treat Sensorineural Hearing Loss by Hair-Cell Regeneration: The Current State of Therapeutic Developments and Their Potential Impact on Audiological Clinical Practice.

These studies demonstrated that two of the four subjects had substantial and clinically meaningful improvements from baseline to day 90 in the WIN test, exceeding the 3.1 dB critical difference set forth by Wilson and McArdle. 49 The four subjects mentioned earlier plus an additional subject that showed a trend in intelligibility improvement returned to the clinic for testing between 13 and 21 months after receiving FX-322.

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