Moreover, although the difference in response magnitude in subjects of each HLA-C*14 subtype did not reach statistical significance for any other individual epitope, the magnitude of T cell responses to Nef epitopes in HLA-C*14:02 + individuals was significantly higher than that in HLA-C*14:03 + individuals, and the magnitude of responses to all 6 epitopes showed a tendency to be higher in HLA-C*14:02 + than HLA-C*14:03 + individuals ( Fig. 6B ).
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Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection.
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