Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.

The difference in tumor incidence between MCPyV-Rb WT and MCPyV-Rb ΔL mice was highly significant (p = 0.0006; two-sided Fisher’s Exact Test).

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We observed similar reductions in E2F-driven luciferase activity in Rb ΔL MEFs compared Rb WT MEFs expressing HPV16E7 (Rb WT vs Rb ΔL MEFs-1 (n = 3): p = 0.01; MEFs-2 (n = 3): p = 0.02; unpaired t-tests) and SV40 LT (Rb WT vs Rb ΔL MEFs-1 (n = 6): p = 0.09; MEFs-2 (n = 3): p = 0.06; unpaired t-tests) although the reduction in SV40 LT-expressing MEFs did not reach statistical significance.

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