Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet.

Lipids Health Dis · 2022 · PMC9134643 · PMID 35614477

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There was 71% down-regulation of C8orf4 in the KO mice and a clear trend of gene-dosage-dependent induction of Sox9, Spp1, and transforming growth factor beta1 (Tgfb1) in HNF4α HET (↑94%, 68%, and 25%, respectively) and KO (↑6.1, 9.8, and 1.9 fold, respectively) mice (Fig. 5 A).

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