Effect of Omega-3 Polyunsaturated Fatty Acids on Lipid Metabolism in Patients With Metabolic Syndrome and NAFLD.

After 12 months of n‐3‐PUFA administration, no significant changes were observed in any of the 1 H MRS‐analyzed parameters, although a nonsignificant trend in the reduction of liver fat content after n‐3‐PUFA supplementation was observed (Table 1 ).

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We observed a trend toward higher fat liver content (evaluated by 1 H MRS) related to the presence of the unfavorable PNPLA3 rs738409 variant, although the difference did not reach statistical significance (data not shown).

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