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Models of enzyme inhibition and apparent dissociation constants from kinetic analysis to study the differential inhibition of aldose reductase.

J Enzyme Inhib Med Chem · 2022 · PMC9135441 · PMID 35607924

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a negative trendno p-value reported
It emerges from the study that a negative trend of app K M / app k cat with the increase of the inhibitor, concentration is an indication that an incomplete inhibition is occurring.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.