Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies.

Compared to control serum, anti-PyTRAP serum was able to modestly but significantly ( p = 0.028) reduce sporozoite invasion of Hepa1-6 hepatoma cells in vitro at a level similar to serum from mice immunized with the recombinant PyCSP ectodomain, although the latter failed to reach significance ( p = 0.106) (Fig. 2b ).

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The improvement afforded by the AKBR-4/anti-PfCSP mAb combination over the efficacy of the anti-PfCSP mAb alone trended toward but did not reach statistical significance at this group size ( p = 0.131).

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