We found that 11 of 39 exosomes [CD9 ( p = 0.024), CD31 ( p = 0.043), CD40 ( p = 0.001), CD41b ( p = 0.036), CD42a ( p = 0.036), CD45 ( p = 0.041), CD62P ( p = 0.041), CD69 ( p = 0.007), CD81 ( p = 0.031), CD105 ( p = 0.020), and HLA-DRDPDQ ( p = 0.031)] were significantly less abundant (based on the equal amount of protein used for the detection of the exosomes in percentage) in pregnant recovered women ( n = 3) than healthy control pregnant women ( n = 7), while CD29 ( p = 0.056) and HLA-ABC ( p = 0.057) were nearly significant ( Figures 1C,D ).
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Dysregulated Exosomes Result in Suppression of the Immune Response of Pregnant COVID-19 Convalescent Women.
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