AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p.

Mol Cancer · 2022 · PMC9137087 · PMID 35624466

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After receiving chemotherapy, patients with CRCs displaying high expression of c-MYC , AP4 or MDC1 showed a trend towards decreased relapse free survival, when compared to patients with low expression of these genes in primary CRCs.

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