Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia.

The most striking and highly significant decrease was demonstrated in hypoxic HIF-1α-depleted cells 48 h after radiation treatment, which is in line with a protective effect of HIF-1 in irradiated cells ( Figure 6 ).

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We observed a minor reduction in cell numbers in HIF-1α KO mHDC which did not reach statistical significance. 3.3.

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