Inflammation and Wasting of Skeletal Muscles in Kras-p53-Mutant Mice with Intraepithelial Neoplasia and Pancreatic Cancer-When Does Cachexia Start?

Cells · 2022 · PMC9139525 · PMID 35626644

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

almost significantp = 0.056so close (0.05 < p ≤ 0.1)

The presence of PDAC resulted in an almost significant ( p = 0.056) decrease in fiber CSA in the gastrocnemius muscle when controlled for the factor sex ( p = 0.238) by ANOVA.

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a strong trendno p-value reported

GSH increases were associated with an out-of-proportion 2.0-fold increase in GSSG, reaching significance in PanIN 1A-B, which indicated a strong trend towards an oxidative shift in GSH redox state in terms of a decrease in the reduced GSH/GSSG ratio with PanIN (0.70-fold), and with PDAC (0.79-fold).

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highly significantno p-value reported

In the soleus muscle, IL-1β expression showed a highly significant seven-fold increase with PDAC independently of the factor sex, while >2-fold increases by trend only were observed for SOCS3 and COX2 but no other signal under study ( Table 3 b).

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