[ 116 ] developed an AAV vector to edit the HBV genome in liver-humanized FRG mice chronically infected with HBV through the CRISPR/Cas9 system and found that the HBV-specific AAV-Cas9 therapy significantly improved the human hepatocytes survival and showed a trend toward decreasing the amount of total liver HBV DNA and cccDNA.
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Therapeutic Application of Genome Editing Technologies in Viral Diseases.
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