Low-Dose Aspirin Augments the Anti-Inflammatory Effects of Low-Dose Lithium in Lipopolysaccharide-Treated Rats.

In evaluating the immobility of Li treated mice, the variation of oral doses revealed that Li doses resulting in blood levels of 1.3 and 1.4 mEq/L induced a highly significant reduction in immobility time, while a dose rendering a blood level of 0.8 mEq/L (considered therapeutically-relevant in humans [ 80 , 81 ]) did not affect immobility time [ 115 ].

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On day 42, LPS treatment by itself resulted in a trend of increased FC TNF-α levels which did not reach statistical significance and was intensified by the addition of aspirin ( Figure 5 d).

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