Neutralizing Antibody Titers in Hospitalized Patients with Acute Puumala Orthohantavirus Infection Do Not Associate with Disease Severity.

Despite not directly correlating with any other measured variable with the exception of PUUV-N IgG antibodies, PUUV neutralizing antibody titers were associated with severe AKI upon hospitalization by GLM analysis and showed a trend of higher levels in patients with more significantly impaired renal function (lower eGFR) in the time series analysis.

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In terms of circulating viral RNA (VL), 45 out of 53 patients had detectable viral RNA in serum but without showing an obvious trend in comparison to FDBH ( Figure 1 C). 3.2.

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