Intervention for Cognitive Reserve Enhancement in Delaying the Onset of Alzheimer's Symptomatic Expression (INCREASE) Study: Results from a Randomized Controlled Study of Medication Therapy Management Targeting a Delay in Prodromal Dementia Symptom Progression.

J Prev Alzheimers Dis · 2022 · PMC9145115 · PMID 36281668

Europe PMC DOI

hedged sentence

0.0680

closest p · 1.4× alpha

0.0680

boldest claim

The sentences

failed to reach statistical significancep=0.068so close (0.05 < p ≤ 0.1)

While our primary analysis of MTM impact on TMTB CR effects failed to reach statistical significance across the combined Aβ-PET SUVr strata, there was a trend for improved cognitive performance on scopolamine-challenged TMTB performance (p=0.068), and consistent with our hypothesis, subgroup analysis using Aβ-PET SUVr cut-offs of 1.4 demonstrated cognitive benefit in the pAD group (SUVr ≥ 1.4; p=0.02).

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