However, age showed a trend towards association with AEs, in accordance with previous studies which found higher rates of CNS-AE in older PLWH and that hypothesized a possible impact of higher drug concentrations in such context, based on a possible but debated correlation between drug exposure and AE probability [ 27 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].
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