Tendon and Ligament Genetics: How Do They Contribute to Disease and Injury? A Narrative Review.

A second study investigating different TNC variants (rs13321; rs2104772; rs1330363) found altered frequencies between cases and controls in Australian and South African populations—but did not reach statistical significance [ 75 ] ( Table 5 ).

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Most GWAS studies have used canine models [ 25 , 26 , 27 ] although one human study highlighted three independent DNA sequence variants associated with ACL rupture—albeit of borderline significance [ 28 ].

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