The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.

Development · 2022 · PMC9148564 · PMID 35552394

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a clear trendno p-value reported

5 C). In a cross targeting all four Gpr124 and Reck alleles with Prx1-Cre , a clear trend was observed in which progressively more digits were lost with the inactivation of more alleles, with a rank order of phenotypic severity Prx1-Cre;Gpr124 CKO/+ ;Reck CKO/+ < Prx1-Cre;Gpr124 CKO/− ;Reck CKO/+ < Prx1-Cre;Gpr124 CKO/+ ;Reck PW/CKO < Prx1-Cre;Gpr124 CKO/− ;Reck PW/CKO ( Fig. 5 D).

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