Notably, CTF-V5 overexpression was sufficient to cause a significant decrease of Nr4a1 , c-Fos , and Npas4 expression, while Egr1 expression did not change, and Cyr61 -expression changes did not reach statistical significance compared with control neurons ( Figure 6 A).
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The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
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