15 Although some trials have showed a trend for better chances of maintaining TFR with longer TKI treatment, none of them has demonstrated to be statistically significant. 11,14,24 In the LALNET recommendations survey, the question regarding minimal time on treatment with TKI to consider discontinuation was answered as follows: 2 years (8%), 3 years, (34%), 4 years (25%), and 5 years (33%).
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Treatment-free remission in patients with chronic myeloid leukemia: recommendations of the LALNET expert panel.
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