<i>Clostridium butyricum</i> therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors.

Oncoimmunology · 2022 · PMC9154751 · PMID 35655708

Europe PMC DOI

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The sentences

showed a trendP = .07so close (0.05 < p ≤ 0.1)

Patients who received PPIs plus antibiotics showed a trend toward shorter PFS (HR 1.65, 95% CI 0.97–2.80, P = .07; Log-rank test P = .06; median, 75 days versus 209 days) and OS (HR 1.62, 95% CI 0.84–3.11, P = .15; Log-rank test P = .15; median, 211 days versus NR) compared with patients who received only PPIs ( Supplementary Figure S4 ).

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