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Beclin1 haploinsufficiency compromises mesenchymal stem cell-offered cardioprotection against myocardial infarction.

Cell Regen · 2022 · PMC9160171 · PMID 35650374

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Although Beclin1 haploinsufficiency did not elicit any discernable effect on baseline or MI-evoked changes in echocardiographic indices (MI-induced rise in LV EDD failed to reach statistical significance in BECN +/− mice), it removed MSCs-induced beneficial effects against MI (Fig. 3 ).

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