Here, we observed highly significant associations with the gene sets ‘G2/M Checkpoint’, ‘Hypoxia’ and ‘E2F Targets’ (Fig. 4 b, Additional file 2 : Supplementary Table 11).
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5'isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1.
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Yet, we observed a trend of reduced tumor growth that failed to reach statistical significance with the limited number of mice used.