The expression of genes encoding alcohol dehydrogenase1 ( Adh1 ) and β-glucuronidase ( Gusb ) in the kidney, glutathione S-transferase pi 1 ( Gstp1 ) in the liver and hydroxy-steroid dehydrogenase 3 beta-6 ( Hsd3b6 ) or reproductive homeobox 5 ( Rhox5 ) in testis was not significantly affected but showed a trend towards for a decrease by AA treatment (Fig. 4f ).
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The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2.
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