Rare CACNA1H and RELN variants interact through mTORC1 pathway in oligogenic autism spectrum disorder.

On the other hand, while the T-type Ca 2+ channels blocker significantly improved pDab1 levels in F2688-1 NPCs, there is still a clear trend towards diminished expression of pDAB1 in these cells compared to untreated control cells (Fig. 3B ), corroborating our previous findings indicating that the variants in the RELN gene contribute to defective levels of this key regulator of Reelin signaling [ 14 ].

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