Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer.

40%) although this did not reach statistical significance when the two groups were compared using Fisher’s exact test.

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Therefore, although not a common mutation found in prostate cancer, its role in CRC could be highly significant especially as it is recognised that β-catenin has the ability to modulate the effects of AR by binding to the NTD, mutations in this region could therefore interfere with this process [ 23 ].

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