Biomarkers of response to PD-1 pathway blockade.

Although one study showed that tumour cell PD-L1 was predictive of response across multiple cancer types while PD-L1 expression on TIIs did not reach statistical significance [ 17 ], other studies have shown that TII PD-L1 expression is more predictive of response than tumour PD-L1 expression [ 59 – 62 ], demonstrating the need for more research into TII PD-L1 expression.

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