Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility.

J Cachexia Sarcopenia Muscle · 2022 · PMC9178400 · PMID 35301823

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

Titin was overall hypo‐phosphorylated compared with ZSF1‐lean ( Figure 6C ) and cGMP levels were lower in LV by 22%, but this did not reach statistical significance (lean: 1 ± 0.07 vs. obese: 0.78 ± 0.07 x‐fold vs. lean; P = 0.07).

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