The Anti-CGRP Antibody Fremanezumab Lowers CGRP Release from Rat Dura Mater and Meningeal Blood Flow.

The mean (± SEM) of all the stimulated release values was 190.9 ± 8.2 pg/mL in the animals treated with the control antibody and 137.5 ± 5.8 pg/mL in the animals treated with fremanezumab; the difference is clearly significant (repeated measures ANOVA and Tukey test, F 1,94 = 32.14, p < 0.001; Figure 1 B, ##).

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