Combination of OX40 Co-Stimulation, Radiotherapy, and PD-1 Inhibition in a Syngeneic Murine Triple-Negative Breast Cancer Model.

The levels of IL-6, a cytokine known to inhibit TGF-β-induced Treg differentiation, were also higher in the two groups treated by α-OX40 and PD-1B with or without RT, although it did not reach statistical significance ( Figure 2 l) [ 34 , 35 ].

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