Extracellular Prostaglandins E1 and E2 and Inflammatory Cytokines Are Regulated by the Senescence Program in Potentially Premalignant Oral Keratinocytes.

In support of this hypothesis, the ATM inhibitor KU55933 had no detectable inhibitory effect, even in OKF6 ( Figure 5 c) or senescent D17 cells ( Figure 5 d), and if anything showed a slight trend towards the stimulation of ePGEs in senescent D17 cells ( Figure 5 d).

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These data are consistent with the celecoxib data, but did not reach statistical significance for ePGE1.

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We treated OKF6 keratinocytes with salicylic acid ( Figure 3 d), NS-398 ( Figure 3 d) and the COX-2 selective inhibitor celecoxib ( Figure 3 e) and showed that all treatments reduced both PGE1 and PGE2 to baseline levels and these results were highly significant.

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