In-Depth Immunological Typization of Children with Sickle Cell Disease: A Preliminary Insight into Its Plausible Correlation with Clinical Course and Hydroxyurea Therapy.

As regards serum immunoglobulins, our data are partially supported by the literature, as in the SCD HU− subgroup, IgG significantly expanded when compared to individuals with a base health condition; the same goes for IgA, although this finding did not reach statistical significance, probably as a consequence of the low sample size [ 30 ].

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