Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain.

Elife · 2022 · PMC9183232 · PMID 35638903

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Overall, STX1A R263E significantly decreased the EPSC amplitude to ~50% compared to that of STX1A WT , whereas the other charge reversal mutants only showed a trend towards a 10–35% decrease in EPSC amplitude ( Figure 2B , Figure 2—figure supplement 1 ).

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