Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates.

Mol Biol Evol · 2022 · PMC9185370 · PMID 35639613

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failed to reach significanceno p-value reported

CICZ was produced by extant orthologous forms tCYP1A5 and hCYP1A2 (and at levels that failed to reach significance in their closely related ancestors N223_1A5_Aves and N127_1A2_Mam), as well as ancestors along the fish lineages, namely N52_1A_Actino and N25_1C_Actino.

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failed to reach statistical significanceno p-value reported

(MB), for which the structure remains to be characterized, was also produced here in minor amounts by tCYP1A5 as well as its direct ancestor, N223_1A5_Aves, at levels that failed to reach statistical significance.

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