Under MPP + treatment, mitochondrial master regulator, PGC-1α (PPARG coactivator 1 alpha), tended to decrease in NPCs but did not reach statistical significance ( p = 0.406), whereas UA treatment significantly upregulated the expression of PGC-1α compared to the only-MPP + -treated group ( p = 0.029, Figure 3E ).
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Uric Acid Enhances Neurogenesis in a Parkinsonian Model by Remodeling Mitochondria.
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