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The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult.

Front Pharmacol · 2022 · PMC9201642 · PMID 35721192

Europe PMCDOI
1
hedged sentence
0.0560
closest p · 1.1× alpha
0.0560
boldest claim

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showed a trendp -value = 0.056so close (0.05 < p ≤ 0.1)
Besides, treatment with UAMC-00050 significantly increased elastase-like activity measured with Suc-Ala-Ala-Ala-AMC (Bonferroni-corrected unpaired t -test p -value = 0.006, Figure 7E ) and showed a trend towards an increase in elastase-like activity measured with Suc-Ala-Ala-Pro-Val-AMC in fecal samples from acute colitis rats (Mann-Whitney U two-sided p -value = 0.056, Figure 7D ). 4 Discussion In this study, we provide new evidence for serine protease inhibitors such as UAMC-00050 and nafamostat as promising therapeutic agents for the treatment of visceral hypersensitivity.

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