In the NCI group, total cPLA2 did not significantly differ between the APOE3/E3 and APOE3/E4 carriers, while the phosphorylated cPLA2 level showed a trend increase in APOE3/E4 carriers as compared to APOE3/E3 carriers (Fig. 4 A).
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Calcium-dependent cytosolic phospholipase A<sub>2</sub> activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
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