An umbrella review on the use of antipsychotics in anxiety disorders: A registered report protocol.

Using a procedure adapted from existent umbrella reviews [ 32 ], we will identify outcomes and interventions for which summary effects showed strong evidence of significance (p<0.001); were based on more than 1000 randomized participants; did not have large heterogeneity between studies (I 2 <75%); their 95% prediction interval excluded the null; extrapolation of the Egger regression line for infinite sample size still suggested a nominally significant effect (i.e., 95% confidence interval did not include the null); had no evidence for excess significance; came from systematic reviews and meta-analysis with a score of at least 9 on the AMSTAR-2 scale; came from systematic reviews and meta-analysis not funded by the entity developing or marketing the intervention and free from authors with a financial conflict of interest associated to the intervention.

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