Integrative multi-omic analysis identifies genetically influenced DNA methylation biomarkers for breast and prostate cancers.

Commun Biol · 2022 · PMC9203749 · PMID 35710732

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0910

boldest claim

The sentences

nominally significantP < 0.05actually significant

For this, we selected the nominally significant hypo- or hypermethylated CpGs (uncorrected P < 0.05) in the discovery step and conducted the overlap step in the pipeline.

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marginally significantP = 0.091so close (0.05 < p ≤ 0.1)

There was a marginally significant increase in the proportion of PrCa CpGs in upstream ( P = 0.091), ncRNA intronic ( P = 0.078) and 5’-UTR + intronic + 3’-UTR ( P = 0.074) regions and a near significant decrease in intergenic region ( P = 0.051) compared to the set of all CpGs tested (Supplementary Data 4 ).

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