Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer.

J Immunother Cancer · 2022 · PMC9204428 · PMID 35705314

Europe PMC DOI

hedged sentence

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

a trend close to significancep=0.051so close (0.05 < p ≤ 0.1)

TMB level was lower in ICI-resistant patients than in ICI-sensitive patients with a trend close to significance (median TMB 20.8 vs 29.3 mutations/Mb, p=0.051) ( figure 4A ), while no significant difference was found in the rest parameters ( online supplemental figure 8 ).

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