A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling.

On day 12, mutant mice displayed more errors and less quadrant time than WT mice, reflecting the trends of impairment in long-term retention, but these differences did not reach statistical significance (Fig. 3J and Supplementary Fig. 2G ).

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