The proportion of patients with diabetes who initiated insulin treatment during follow-up was lower in the sacubitril/valsartan group than in the valsartan group, but the difference did not reach statistical significance (12.8% vs. 16.1%; HR: 0.80, 95% CI 0.62–1.02, P = 0.07).
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Effects of sacubitril/valsartan on glycemia in patients with diabetes and heart failure: the PARAGON-HF and PARADIGM-HF trials.
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