ProMetheusDB: An In-Depth Analysis of the High-Quality Human Methyl-proteome.

Mol Cell Proteomics · 2022 · PMC9207298 · PMID 35577067

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a strong trendno p-value reported

Since our group previously observed a strong trend of methylated proteins to be part of multisubunit complexes ( 9 ), we asked whether this observation still held true in this expanded dataset: we found that hypermethylated proteins (bearing five or more R-methyl-sites) presented significantly higher node degree and network centrality compared with nonmethylated proteins detected in the input samples ( Fig. 3 C ).

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