Mincle-binding DNA aptamer demonstrates therapeutic potential in a model of inflammatory bowel disease.

Mol Ther Nucleic Acids · 2022 · PMC9207717 · PMID 35782912

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0.0680

closest p · 1.4× alpha

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showed a trendp = 0.068so close (0.05 < p ≤ 0.1)

Analysis of colon sample lysates using western blot and band densitometry analysis showed a trend toward a reduction of DSS-induced total Syk (p = 0.068) and P65 phosphorylation within the tissue in mice treated with the highest dose of AptMincle DRBL ( Figures 3 F and 3G).

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