Changes in the Expression of Insulin Pathway, Neutrophil Elastase and Alpha 1 Antitrypsin Genes from Leukocytes of Young Individuals with Insulin Resistance.

46–49 In the IR group, serum insulin and HOMA-IR levels were observed to be elevated twofold; however, in the OB-IR group, these values were elevated almost fourfold compared to those of the NIR group, with a slight trend toward increased glucose levels.

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However, when comparing NIR and IR individuals with OB-IR, an increase in NE and A1AT expression and a clear trend towards a decrease in IRS-2 expression was observed, whereas the comparison of IR and OB-IR showed a decrease in GLUT-3 expression.

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