The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies.

Antioxidants (Basel) · 2022 · PMC9220017 · PMID 35739987

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did not reach statistical significanceno p-value reported

Furthermore, single-agent doxercalciferol was studied in CRPC (12.5 mg per os) among 26 patients: it did not reach statistical significance, with no substantial decrease in PSA; paricalcitol was evaluated on a 3-times-per-week schedule and, while it was very well tolerated and safe to use, it did not demonstrate a serum PSA reduction [ 147 , 148 ].

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