Modulating Microglia/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model.

Biomedicines · 2022 · PMC9221078 · PMID 35740467

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Interestingly, RNA sequencing further revealed that CDNF treatment exhibits a strong trend of upregulation of genes related to protein kinase B signaling (Akt signaling pathway), such as Igf1, MerTK, PI3Kcd, and PI3Kcg, in 6-OHDA-stimulated BV2 microglia cells.

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