Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens.

50%) trended to a higher mutation frequency in Stage IIIA compared to Stage I cancers, although this did not reach statistical significance ( Table 2 ).

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This finding may be significant if observed in advanced CRC, as it highlights a potential vulnerability which may be exploited therapeutically using the combination of agents that cause DNA single strand breaks and PARP inhibitors.

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