Analgesics Induce Alterations in the Expression of SARS-CoV-2 Entry and Arachidonic-Acid-Metabolizing Genes in the Mouse Lungs.

Pharmaceuticals (Basel) · 2022 · PMC9227818 · PMID 35745615

Europe PMC DOI

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closest p · 2.0× alpha

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The sentences

failed to reach statistical significancep = 0.10so close (0.05 < p ≤ 0.1)

Although the NSAIDs ibuprofen and diclofenac upregulated the expression of TMPRSS2 gene by 4 and 2.6 folds, respectively ( Figure 4 B), this upregulation of TMPRSS2 by NSAIDs failed to reach statistical significance ( p = 0.10–0.27).

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