Measurement of Tetrahydrobiopterin in Animal Tissue Samples by HPLC with Electrochemical Detection-Protocol Optimization and Pitfalls.

Antioxidants (Basel) · 2022 · PMC9228106 · PMID 35740082

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We were also not able to establish a significant decrease in BH 4 levels in the aorta of diabetic rats (after separation of BH 4 from ascorbate) but observed a significant increase of BH 4 concentrations in the heart and kidney and also a clear trend of increased BH 4 levels in the brains of septic rats.

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